INDIANAPOLIS, Dec. 1, 2025 -- Eli Lilly and Company (NYSE: LLY) announced Zepbound® (tirzepatide) single-dose vials will now be available at lower prices on LillyDirect, the company’s digital healthcare platform. This update builds on Lilly’s ongoing efforts to lower out-of-pocket costs for people living with obesity in the United States. Last month, Lilly announced lower prices for Zepbound multi-dose pens, subject to approval by the Food and Drug Administration (FDA). By lowering prices of Zepbound single-dose vials, Lilly is offering patients greater access and optionality with their treatment options.
With a valid prescription, patients can access the starting dose of Zepbound single-dose vial (2.5 mg) for as low as $299 per month. The 5 mg dose will be available at $399 per month. All other approved doses are $449 per month for patients in the Zepbound Self Pay Journey Program. 1
“Far too many people who need obesity treatments still face cost and coverage barriers,” said Ilya Yuffa, executive vice president and president, Lilly USA and Global Customer Capabilities. “Today’s action underscores Lilly’s commitment to improving access across the obesity care landscape. We will keep working to provide more options – expanding choices for delivery devices and creating new pathways for access – so more people can get the medicines they need.”
*Regular prices (per month) when not purchased via the Zepbound Self-Pay Journey Program: $599 for 7.5 mg, $699 for 10 mg, $849 for 12.5 mg, $1,049 for 15 mg.
Zepbound is an injectable prescription medicine that may help adults with obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. It may also help adults with moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA. Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known whether Zepbound is safe and effective for use in children.
Zepbound is also available in 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL doses in a single-dose pen (autoinjector). The 2.5 mg is a starting dose and not an approved maintenance dose. The recommended maintenance doses are 5 mg, 10 mg, or 15 mg injected subcutaneously once per week for weight reduction and long-term maintenance. The recommended maintenance doses are 10 mg or 15 mg for OSA.
Additional resources and details are available on Zepbound.lilly.com. Visit LillyDirect.lilly.com to learn more about pricing, eligibility and delivery options.
About Lilly
Lilly is a medicine company turning science into healing to make life better for people around the world. We’ve been pioneering life-changing discoveries for nearly 150 years, and today our medicines help tens of millions of people across the globe. Harnessing the power of biotechnology, chemistry and genetic medicine, our scientists are urgently advancing new discoveries to solve some of the world's most significant health challenges: redefining diabetes care; treating obesity and curtailing its most devastating long-term effects; advancing the fight against Alzheimer’s disease; providing solutions to some of the most debilitating immune system disorders; and transforming the most difficult-to-treat cancers into manageable diseases. With each step toward a healthier world, we’re motivated by one thing: making life better for millions more people. That includes delivering innovative clinical trials that reflect the diversity of our world and working to ensure our medicines are accessible and affordable.
1 Zepbound Self Pay Journey Program lowers the price of the 7.5 mg, 10 mg, 12.5 mg and 15 mg vials only on first fill and when prescriptions are refilled within 45 days of their previous delivery. The 12.5 mg and 15 mg vials are priced at $849 and $1,049, respectively, if refilled outside of the 45-day window.
