专注于肝外靶向小核酸药物研发的国际化创新药企蔚程医药有限公司（Vivatides Therapeutics）宣布顺利完成超额认购的5400万美元A轮融资。
本轮融资由启明创投与一家知名产业基金联合领投，弘晖基金、一家知名投资基金、泰福资本共同积极参与投资，原有投资方杏泽资本持续追加投资。本轮融资资金将主要用于公司核心肝外递送技术平台的迭代优化、多条管线的临床推进，以及团队扩充与全球研发网络搭建。
作为小核酸赛道的新兴力量，蔚程医药在成立不足一年时间内连续完成种子轮与A轮融资，彰显了投资市场对公司在肝外小核酸领域技术突破能力与高效执行力的高度认可。
小核酸药物凭借靶点丰富、特异性强、疗效持久等优势，将成为继小分子、抗体药物之后的第三大主流疗法。传统小核酸药物受限于递送技术，多数集中于肝脏靶向领域，而肝外组织相关疾病的治疗需求长期未被满足，成为行业公认的下一代技术突破方向。随着肝外递送技术的兴起，小核酸药物的适应症正从罕见病向高血脂、高血压、肿瘤等慢性病领域快速延伸，市场空间实现指数级扩容。
蔚程医药自2025年成立以来，始终聚焦肝外小核酸递送技术的自主创新与转化。公司国际化核心团队由来自Arrowhead、Ionis、Alnylam、Dicerna等全球小核酸龙头企业的资深专家组成，曾主导多个肝外管线开发与平台搭建，团队成员此前累计主导或深度参与的肝外小核酸项目中，多个已进入临床开发阶段。 依托国际化团队的技术积累，蔚程医药构建了具有差异化优势的肝外递送平台，且兼具siRNA和ASO的核心研发能力。在配体偶联、递送效率、组织靶向精准度及安全性上实现关键突破，目前已在动物实验中取得实质性进展，结合领先的序列设计和靶点开拓能力，为多管线并行快速推进和扩充奠定了坚实基础。
“肝外靶向递送是小核酸技术从‘小众罕见病’走向‘大众慢病’的核心钥匙。”蔚程医药创始人周科明博士表示，“公司很荣幸获得多家顶尖投资机构的支持与认可。本轮融资将加速我们的技术平台迭代与管线开发，推动创新小核酸疗法在肝外疾病领域的临床转化。我们坚信，通过突破递送瓶颈，小核酸药物将在更广泛的疾病领域实现治疗范式革新。我们也期待与更多长期价值导向的伙伴进一步交流与合作，为全球患者带来全新治疗选择。”
启明创投合伙人、医疗创新行业共同负责人陈侃博士表示：“我们长期看好小核酸药物在更广泛疾病领域的应用潜力，肝外靶向技术的持续进步正不断拓展其临床边界。蔚程医药在该方向展现出扎实的技术积累和高效的执行能力，其平台已取得积极进展。我们期待公司持续推动技术突破，加速管线向临床转化，为全球患者带来更安全、有效的创新疗法。”
原有投资方杏泽资本合伙人丁巍博士表示：“作为蔚程种子轮投资方，我们很高兴见证公司高效完成A轮融资，欢迎新投资人的加入。自公司成立以来，我们欣慰地看到，周科明博士带领的团队凭借极高的执行效率，在平台迭代与管线推进上持续超预期。期待蔚程加速将其差异化创新平台转化为惠及全球患者的突破性疗法，继续领跑肝外靶向核酸药物的研发浪潮。”
本轮融资后，蔚程医药将进一步加快临床前管线的优化与IND申报准备，同时持续扩充研发与管理团队，深化肝外递送技术的平台化建设。未来，公司将以满足未被满足的临床需求为核心，聚焦高发病率、高需求的肝外疾病领域，打造全球领先的肝外小核酸药物研发企业，为全球患者提供更高效、更安全的创新疗法。
关于蔚程医药
蔚程医药基于自主研发的肝外递送技术平台，主攻小核酸药物在非肝组织的靶向递送，旨在突破传统小核酸药物局限于肝内递送的技术瓶颈。核心使命是通过创新技术突破小核酸药物在肝外组织的递送，满足未尽的医疗需求。
关于启明创投
启明创投成立于2006年。目前，启明创投旗下管理11只美元基金，7只人民币基金，已募管理资产总额达到95亿美元。自成立至今，专注于投资科技(Technology)、医疗创新(Healthcare)等行业早期和成长期的优秀企业。
截至目前，启明创投已投资超过580家高速成长的创新企业，其中有超过210家分别在美国纽交所、纳斯达克，香港交易所，上交所及深交所等交易所上市，或通过并购等方式退出，有80多家企业成为行业公认的独角兽或超级独角兽企业。
关于弘晖基金
弘晖基金成立于2014年，是一家专注于科技领域长期价值的专业投资机构，团队紧跟国家新质生产力发展战略，始终坚定服务于中国式现代化，专注发掘和实现科学技术的恒久价值。基于在生物化学、前沿技术、精密制造、高端装备、材料工程等核心领域的深刻认知，立足独立深度研究和体系化赋能服务，弘晖基金矢志通过对实体经济和科技创新的长期价值投资，为生产效率的变革、人民健康生活的提升创造持续积极影响。
截至目前，弘晖基金已经投资和培育了数十家上市公司和行业领军企业，如迈瑞医疗(300760.SZ)、联影医疗(688271.SH)、药明康德(603259.SH)、康龙化成(300759.SZ)、泰格医药(03347.HK)、威高血净(603014.SH)、博瑞医药(688166.SH)、鱼跃医疗(002223.SZ)、浩欧博(688656.SH)、维亚生物(1873.HK)、劲方医药（2595.HK）、思摩尔国际(6969.HK)、兆维科技、长江存储、众擎机器人、千寻智能、亚电科技、首形科技、富兴电机、蓝色向量、和生创新、电科星拓、拓烯科技等。
关于泰福资本
泰福资本聚焦于生命科学领域的风险投资,主要投资有潜力的早期及成长期企业。通过多元化、战略性布局，选择优质的合作伙伴，期望在中国生命科学的快速发展中把握机会。投资团队在这些领域有多年经验及行业资源，希望与被投资企业共同快速成长。
关于杏泽资本
上海杏泽投资管理有限公司（“杏泽资本”） 成立于2015年，由全球20多位富有医疗健康领域投资经验的专业人士及顾问组成，取“杏泽”之名，意在通过股权投资，借资本之力整合大健康产业资源，促行业发展，以福泽人类。目前旗下管理6支人民币基金，管理资产总额近65亿元。
成立至今，杏泽资本专注于投资生命科学行业中早期和成长期的优秀企业，投资领域专注于创新生物医药、医疗器械（包括高端生命科学仪器）和创新服务产业链。已投资公司包括君实生物（01877HK、688180.SH）、康方生物（09926.HK）、中国抗体（03681.HK）、荣昌生物（688331.SH、09995.HK）、心通医疗（02160.HK）、微创电生理（688351.SH）、Ambrx(NYSE:AMAM)、劲方医药（02595.HK）、六合宁远、宜联生物、齐禾生科、舶望制药、天泽云泰、先声再明、亦诺微、蔚程医药、翎泰天润、昂拓生物、医药魔方等70余家高速成长的明星企业。
Vivatides Therapeutics Announces Oversubscribed $54 Million Series A Financing to Accelerate Extrahepatic RNA Therapeutics Development
– Advancing next-generation RNA therapeutics beyond the liver through breakthrough delivery technologies
Vivatides Therapeutics, a global biotechnology company focused on developing extrahepatic RNA-targeting therapeutics, announced the successful closing of an oversubscribed $54 million Series A financing. The round was co-led by Qiming Venture Partners and a leading industry fund, with participation from Highlight Capital, a leading venture fund, and TF Capital. Existing investor Apricot Capital also continued to support the company with additional investment. Proceeds from the financing will be used to further advance Vivatides’ extrahepatic delivery platform, accelerate multiple pipeline programs into clinical development, and expand its global team and R&D network. As an emerging player in the RNA therapeutics field, Vivatides has completed both its seed and Series A financings within less than one year of founding, underscoring strong investor confidence in the company’s technological innovation and execution capabilities in extrahepatic RNA delivery.
RNA therapeutics, with their broad target space, high specificity, and durable efficacy, are poised to become the third major therapeutic modality following small molecules and antibodies. However, traditional RNA therapeutics have largely been limited to liver-targeted applications due to delivery challenges. Diseases involving extrahepatic tissues remain significantly underserved and represent the next major frontier for innovation.
With advances in extrahepatic delivery technologies, RNA therapeutics are rapidly expanding beyond rare diseases into large, chronic disease areas such as hyperlipidemia, hypertension, and oncology, unlocking substantial market potential.
Founded in 2025, Vivatides has been dedicated to the innovation and translation of proprietary extrahepatic RNA delivery technologies. The company’s globally experienced leadership team includes experts from leading RNA therapeutics companies. The team has previously led or played key roles in multiple extrahepatic RNA programs, several of which have progressed into clinical development. Leveraging this deep expertise, Vivatides has built a differentiated extrahepatic delivery platform with capabilities spanning both siRNA and antisense oligonucleotides (ASO). The company has achieved key advances in ligand conjugation, delivery efficiency, tissue targeting specificity, and safety, with encouraging in vivo results already demonstrated. Combined with strong capabilities in sequence design and target discovery, the platform enables rapid parallel advancement and expansion of a diversified pipeline.
“Extrahepatic delivery is the key that will unlock RNA therapeutics from niche rare diseases to broad chronic indications,” said Keming Zhou, Founder of Vivatides Therapeutics. “We are honored to have the support and recognition of leading investors. This financing will accelerate the evolution of our platform and pipeline, advancing innovative RNA therapeutics into extrahepatic disease areas. We believe that overcoming delivery barriers will enable RNA therapeutics to transform treatment paradigms across a wide range of diseases. We also look forward to engaging with more long-term, value-driven partners to bring transformative therapies to patients worldwide.”
Dr. Kan Chen, Partner at Qiming Venture Partners and Co-leads Qiming's investments in the healthcare sector, commented: " We have long been optimistic about the application potential of small nucleic acid drugs across a broader range of disease areas. Continuous advances in extrahepatic targeting technologies are steadily expanding their clinical frontiers. Vivatides Therapeutics has demonstrated solid technological expertise and efficient execution capabilities in this field, with encouraging progress achieved on its platform. We look forward to the company driving further technological breakthroughs, accelerating the clinical translation of its pipeline, and delivering safer and more effective innovative therapies to patients worldwide."
Dr. Wei Ding, Partner at Apricot Capital, commented: “As an early investor in Vivatides’ seed round, we are delighted to see the company successfully complete its Series A financing and welcome new investors. Since its founding, Dr. Zhou and his team have consistently exceeded expectations with exceptional execution in platform development and pipeline advancement. We look forward to Vivatides translating its differentiated platform into breakthrough therapies that benefit patients worldwide and leading the next wave of extrahepatic RNA therapeutics.”
Following the financing, Vivatides will further accelerate preclinical optimization and IND-enabling studies, expand its R&D and management teams, and continue to strengthen its extrahepatic delivery platform. Looking ahead, the company will remain focused on addressing unmet medical needs in high-prevalence extrahepatic diseases, becoming a leader in RNA therapeutics and delivering more effective and safer treatment options to patients worldwide.